Topic: Integrating genomics to guide clinical care: Laying the foundational processes through implementation of genotype-guided antiplatelet therapy
Speaker: Nita A. Limdi, Pharm.D, Ph.D, MSPH, FAHA, Professor Department of Neurology, The University of Alabama at Birmingham
PGx promises to improve patient outcomes optimizing drug therapy. Evidence that tailored genotype-guided therapy (GGTx) can improve outcomes is growing. Despite advances in genotyping technology and decreasing costs, therapeutic use remains limited in part due to the complexity of enterprise-wide implementation of GGTx. Integration of research and implementation efforts across a seamless framework can enable learning health-care systems to realize the promise of pharmacogenomics for the individual patient and the population. The University of Alabama at Birmingham created an institutional framework for implementing genomic guided therapies. This framework can provide a valuable template for other institutions planning to implement pharmacogenomics and disease prediction/ stratification precision medicine interventions. I will present genotype-guided antiplatelet therapy as a proof-of-concept example and demonstrate that GGTx is feasible (turnaround-time 70 minutes), 30% of patients in our population possessing actionable genotype, and acceptance of alternate treatment recommendations in 70% of patients.
Webinar Slides: Informatics_Ignite_PGX_implement_March2018_rev