St. Jude Children’s Research Hospital provides comprehensive inpatient and outpatient care for children with catastrophic diseases, focusing on childhood cancer, infectious diseases, and sickle cell disease. St. Jude has a long history of research and discovery in pharmacogenetics and genomics. Our translational research experience combined with clinical and laboratory expertise in therapeutic drug monitoring have formed the foundation of our efforts to implement pharmacogenetics as standard of care for our patients. Most St. Jude patients are eligible to enroll in an ongoing clinical trial called PG4KDS, a research protocol designed to implement preemptive pharmacogenetic test results into routine clinical care (www.stjude.org/pg4kds). St. Jude has a fully functional and integrated electronic health record (EHR) system from Cerner Corporation.