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CAG is one of ten Centers for Emphasis of the Children’s Hospital of Philadelphia (CHOP). The CHOP Health Care Network includes over 50 practice sites throughout Pennsylvania and New Jersey which are live on the EpicCare EMR system. CHOP has assembled the components of the country’s largest pediatric integrated delivery system, supporting >1.1 million visits/year within the primary and specialty care networks, community-based inpatient pediatric and neonatal programs, a rehabilitation hospital, and a home care service. It provides acute- and well-care to patients in urban, rural, and suburban settings. CAG’s mission is to develop new and better ways to diagnose and treat children affected by both common and rare complex medical disorders. We aim to discover genetic causes for the most prevalent diseases of childhood including asthma, autism, diabetes, epilepsy, obesity, schizophrenia, and pediatric cancers. Ultimately, CAG’s objective is to generate new diagnostic tests and to guide physicians to the most appropriate therapies.