Group Health Cooperative with the University of Washington and the Fred Hutchinson Cancer Research Center (GHC/UW) as part of the Seattle eMERGE project aims to bring personal genomics to practice settings by taking advantage of the extensive electronic medical record (EMR) and biorepository of Group Health Cooperative (GHC), including a pharmacy database and longitudinal data on an aging population. The team has created a model for introducing genomics into clinical practice, performed successful needs assessment methods from eMERGE Phase I will engage stakeholders in guiding development of prototype EMR user interfaces in a clinical decision support format utilizing natural language processing. To disseminate eMERGE results and foster collaborations, GroupHealth leverages its advantage of leadership positions of the investigators (including partners within eMERGE, other consortia and the HMO Research network, especially the potential for developments supported by the NIH Director’s markers), improve the linking of high-throughput genomic methods to EMR data, and develop policies and practices for bringing individualized evidence-based medicine to communities.