Enabling Personalized Medicine in clinical care to improve health profiles in diverse communities is a top priority in the strategic plan of The Icahn School of Medicine at Mount Sinai. Mount Sinai serves diverse communities of New York City with broad health disparities. Mount Sinai Medical Center and the Institute for Personalized Medicine (IPM) are committed to share these unique resources to advance genomic medicine, as a member of the eMERGE II Network and to advance the clinical translation of genomic knowledge to reduce health disparities and improve health outcomes in diverse communities. IPM looks to provide investigators with greater and easier access to high quality standardized data linked with longitudinal clinical information, and with technology support for discovering clinically important genotype-phenotype associations. IPM facilitates clinical development of gene-based diagnostics and risk assessment algorithms and evaluates their impact on health care delivery at the patient and population level.